Alpha Lipoic Acid (ALA) regulates glucose metabolism
Alpha-lipoic acid increases insulin sensitivity and stimulates glucose uptake into adipose and muscle cells due to its stimulation of insulin receptor in tissues.(1 ,2)
This action increases usage of glucose in tissues and decreases the glucose blood concentration
Reduction of glucose blood concentration in diabetes model by 45% (3,4)
Alpha Lipoic Acid (ALA) is an important an/oxidant
Exogenous alpha-lipoic acid orally administered is used for the symptomatic treatment of diabetic polyneuropathy. (6) AL A participate in the recycling of other important biologic antioxidants, such a vitamins E and C, ubiquinone and glutathione (5)
Literature
1 [Cho KJ et al; Biochem Pharmacol 66 (5): 849-58 (2003)]
2 [Moini H et al; Toxicol Appl Pharmacol 182 (1): 84-90 (2002)]
3 189 ± 48 v 341 ± 36 mg/dL after 12-hour fast
4 Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats Mogher Khamaisi, Ruth Potashnik, Amir Tirosh, Eran Demshchak, Assaf Rudich, Hans Trischler, Klus Wessel, Nava Bashan, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel , ASTA Medica, Frankfurt, Germany Metabolism, Volume 46, Issue 7, July 1997, Pages 763–768
5 Alpha-Lipoic acid – Substance Summary (SID 50107043) Also known as: NCGC00094396-02 6 Teichert J et al; J Clin Pharmacol 43 (11):1257-67 (2003)]
7 [Moini H et al; Toxicol Appl Pharmacol 182 (1): 84-90 (2002)]
8 [Choi SY et al; Ann N Y Acad Sc 1171: 149-55 (2009)]